Endocrine Abstracts

Cystic ovarian disease is a common reproductive disorder in women and females of domestic animals, leading to temporal or permanent infertility. Over one in three women with polycystic ovarian syndrome (PCOS) are overweight and have higher serum leptin concentration. Leptin may thereby mediate some of the adverse effect of obesity on ovarian function.In the presented data, we decided to compare the action of two high doses of leptin (20 ng and 40 ng/ml) ...

The recommended amount of administered radioiodine activity needed to successfully ablate thyroid remnants after total thyroidectomy is controversial. We compared the efficacy of 50mCi and 100mCi radioactive iodine for thyroid remnant ablation among patients with low stage and low to intermediate risk differentiated thyroid cancer who underwent total thyroidectomy through a retrospective cohort study in a tertiary multi-specialty referral center located in Quezon City, Philipp...

PCOS is a complex endocrine syndrome characterized by the combination of reproductive aberrations, namely hyperandrogenism and chronic anovulation, with metabolic defects. Insulin resistance is a major component in metabolic as well as reproductive aspects of PCOS. The pathogenesis of the syndrome remains under investigation. However, environmental factors appear to unmask a genetically determined susceptibility to PCOS and also determine the specific phenotypic expression of ...

E R Simpson, Prince Henry's Institute, Clayton, Victoria, Australia. AbstractDr Evan Simpson is a native of Edinburgh, Scotland. He has had a long interest in the basic biology of estrogen biosynthesis, especially its relationship to breast cancer.His group was the first to clone and characterize the aromatase gene and to show the unique use of tissue-specific promoters to regulate tissue-specif...

Background: Adolescence is a time of change and is associated with a deterioration in glycaemic control. Education is an important part of diabetes care and enables patients to understand how to manage their condition. An audit was carried out to assess whether adolescents with type 1 diabetes were being educated about social aspects of diabetes.Method: Fifteen adolescents between the ages of 13 and 17 were asked to subjectively score their knowledge of ...

Several recent animal studies have revealed that the gonad is particularly sensitive to exposures to endocrine disrupters during the early fetal period, when sex differentiation occurs. Thus exposure to doses of phthalates, which have small or no effects when given to adult rats, can have pronounced effects in male offspring of pregnant rats exposed to the same doses of DEHP and DBP. At certain dose levels the effects include severe dysgenesis of the testis, undescended testis...

The pharmacologic armamentarium available to clinicians to reduce fracture risk in women with postmenopausal osteoporosis consists essentially of antiresorptive agent. Recently, peptides from the parathyroid hormone (PTH) family, which under specific modalities of administration act as anabolic agents have become available. The interest generated by these alternatives to antiresorptive treatment resides in their greater potential for restauration of bone mass and possibly also...

P E Clayton, Endocrinology and Diabetes Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK AbstractPeter Clayton is Professor of Child Health and Paediatric Endocrinology in the Faculty of Medical and Human Sciences at the University of Manchester. He is an honorary consultant at the Royal Manchester Children’s Hospital and at the Christie Hospital and is the Director of t...

Growth is an inherent property of life. Normal somatic growth requires the integrated function of many of the hormonal, metabolic, and other growth factors involved in the hypothalamo-pituitary-growth axis. Discovery of transcription factors responsible for pituitary cell differentiation and organogenesis has had an immediate impact on understanding and diagnosis of pituitary hormone deficiencies. Importantly, combined pituitary hormone deficiencies (CPHD) have been associated...

Mark E Molitch, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA AbstractMark E. Molitch, MD, is Professor of Medicine and a Member of the Division of Endocrinology, Metabolism and Molecular Medicine at Northwestern University Feinberg School of Medicine, in Chicago, Illinois. Prior to joining the faculty at Northwestern in 1984, Dr. Molitch was an Associate Professor at Tufts University School of...